Reading Time: 5 minutesIn spite of the evolution of lipid-lowering therapies, the presence of persistent, chronic inflammation continues to drive cardiovascular disease risk independent of lipid biomarkers. Studies have demonstrated improved atherosclerotic outcomes when inflammation itself is directly targeted on top of blood lipids. Identification of the upstream source of dysfunctional inflammatory resolution remains the…

Reading Time: 3 minutesMy previous post dove into some of the mechanisms underlying cardiovascular disease, including metabolic disturbance, vasculature stiffening, endothelial dysfunction, poor mitochondrial performance, oxidative stress, and chronic inflammation. Age-associated senescence is another contributor to low-grade inflammation. Senescent cells secrete a variety of injurious and immune-activating compounds which characterize their pro-inflammatory, senescence-associated secretory phenotype…

Reading Time: 6 minutesAs a leading cause of death globally, cardiovascular disease remains one of the greatest threats to long term health. Cardiac muscle requires a perpetual and consistent source of fuel to sustain a regular heartbeat and corresponding nutrient delivery to peripheral tissues. This type of energy is largely supplied by mitochondrial oxidation of…

Reading Time: 5 minutesThe thyroid gland is the master metabolic regulator, coordinating the metabolism of every bodily organ and system. The thyroid and the brain are intricately linked through the hypothalamic-pituitary-thyroid axis. The brain acts as the conductor, informing the thyroid of hormone needs. Thyroid hormones in turn support neurological function by stimulating energetic pathways…